A prepro-orexin gene polymorphism is associated with narcolepsy.

نویسندگان

  • M Gencik
  • N Dahmen
  • S Wieczorek
  • M Kasten
  • J Bierbrauer
  • I Anghelescu
  • A Szegedi
  • A M Menezes Saecker
  • J T Epplen
چکیده

The orexin (hypocretin) neurotransmitter system was recently shown to be directly involved in the pathogenesis of narcolepsy in two animal models. Furthermore, decreased levels of orexin A in the CSF were shown in narcoleptic patients. To define any genetic contribution of orexin to the etiology of narcolepsy, the authors screened the entire prepro-orexin gene for mutations or polymorphisms in 133 patients suffering from narcolepsy. They report an association of a rare polymorphism in the prepro-orexin gene with narcolepsy in a cohort of 178 patients.

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OX1 and OX2 orexin/hypocretin receptor pharmacogenetics

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عنوان ژورنال:
  • Neurology

دوره 56 1  شماره 

صفحات  -

تاریخ انتشار 2001